تلوث البيئه

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نوع الوثيقة : مقال في مجلة دورية  عنوان الوثيقة : مكونات الهواء تؤثر على تكوين الثرومبين في الناس الأصحاء. مشروع RAPTES Components of ambient air pollution affect thrombin generation in healthy humans: the RAPTES project   الموضوع : علوم البيئة  لغة الوثيقة : الانجليزية  المستخلص : ABSTRACT Objectives Increases in ambient particulate matter (PM) have been associated with an elevated risk of stroke, myocardial ischaemia and coronary heart disease, with activation of blood coagulation likely playing an important role. PM-mediated activation of two major activation pathways of coagulation provides a potential mechanism for the observed association between PM and cardiovascular disease. However, it remains unclear which specific characteristics and components of air pollution are responsible. Methods In order to investigate those characteristics and components, we semiexperimentally exposed healthy adult volunteers at five different locations with increased contrasts and reduced correlations among PM characteristics. Volunteers were exposed for 5 h, exercising intermittently, 3–7 times at different sites from March to October 2009. On site, we measured PM mass and number concentration, its oxidative potential (OP), content of elemental/organic carbon, trace metals, sulphate, nitrate and gaseous pollutants (ozone, nitrogen oxides). Before and 2 and 18 h after exposure we sampled blood from the participants and measured thrombin generation using the calibrated automated thrombogram. Results We found that thrombin generation increases in the intrinsic (FXII-mediated) blood coagulation pathway in relation to ambient air pollution exposure. The associations with NO2, nitrate and sulphate were consistent and robust, insensitive to adjustment for other pollutants. The associations with tissue factor-mediated thrombogenicity were not very consistent. Conclusions Ex vivo thrombin generation was associated with exposure to NO2, nitrate and sulphate, but not PM mass, PM OP or other measured air pollutants.  ردمد : 1351-0711  اسم الدورية : OCCUPATIONAL AND ENVIRONMENTAL MEDICINE  المجلد : 70  العدد : 5  سنة النشر : 1434 هـ 2013 م  نوع المقالة : مقالة علمية  تاريخ الاضافة على الموقع : Tuesday, June 4, 2013

الباحثون اسم الباحث (عربي) اسم الباحث (انجليزي) نوع الباحث المرتبة العلمية البريد الالكتروني Maciej Strak Strak, Maciej باحث     Gerard Hoek Hoek, Gerard باحث     Maaike Steenhof Steenhof, Maaike باحث     Evren Kilinc Kilinc, Evren باحث     Krystal J. Godri Godri, Krystal J. باحث     Ilse Gosens Gosens, Ilse باحث     Ian S Mudway Mudway, Ian S باحث     Rene van Oerle van Oerle, Rene باحث     Henri M. H Spronk Spronk, Henri M. H باحث     Flemming R Cassee Cassee, Flemming R باحث     Frank J Kelly Kelly, Frank J باحث     Roy M Harrison Harrison, Roy M باحث     Bert Brunekreef Brunekreef, Bert باحث     Erik Lebret Lebret, Erik باحث     Nicole A. H Janssen Janssen, Nicole A. H باحث   nicole.janssen@rivm.nl